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当结构和电子类比导致反应活性时：钒酸盐前所未有的磷酸二酯酶活性。

When structural and electronic analogy leads to reactivity: the unprecedented phosphodiesterase activity of vanadates.

作者信息

Steens Nele, Ramadan Ahmed M, Parac-Vogt Tatjana N

机构信息

Katholieke Universiteit Leuven, Department of Chemistry, Celestijnenlaan 200F, B-3001 Leuven, Belgium.

出版信息

Chem Commun (Camb). 2009 Feb 28(8):965-7. doi: 10.1039/b816785k. Epub 2008 Dec 18.

DOI:10.1039/b816785k
PMID:19214331
Abstract

The interaction between an RNA model phosphodiester and oxovanadate complexes results in a purely hydrolytic cleavage of a phosphodiester bond under physiological pH and temperature: a comparison of the rate-pH profile with the species distribution diagram indicates that the negatively charged tetravanadate V(4)O(12), which forms at toxic vanadium levels, is the hydrolytically active species.

摘要

一种RNA模型磷酸二酯与氧钒酸盐配合物之间的相互作用，在生理pH值和温度下会导致磷酸二酯键发生纯粹的水解断裂：将速率-pH曲线与物种分布图进行比较表明，在有毒钒水平下形成的带负电荷的四钒酸盐V(4)O(12)是具有水解活性的物种。

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