Calvo Fernanda Bernardes, Santos Junior Dário, Rodrigues Consuelo Junqueira, Krug Francisco José, Marumo Júlio Takehiro, Schor Nestor, Bellini Maria Helena
Instituto de Pesquisas Energéticas e Nucleares, Cidade Universitária IPEN-CNEN/SP, São Paulo, Brazil.
Biol Trace Elem Res. 2009 Aug;130(2):107-13. doi: 10.1007/s12011-009-8325-x. Epub 2009 Feb 13.
The development of cancer is a complex, multistage process during which a normal cell undergoes genetic changes that result in phenotypic alterations and in the acquisition of the ability to invade other sites. Inductively coupled plasma optical emission spectroscopy was used to estimate the contents of Al, Ca, Cd, Cr, Cu, Fe, K, Mg, Mn, Na, P, Pb, and Zn in healthy kidney and renal cell carcinoma (RCC), and significant differences were found for all elements. Along with the progression of the malignant disease, a progressive decrease of Cd and K was observed. In fact, for Cd, the concentration in stage T4 was 263.9 times lower than in stage T1, and for K, the concentration in stage T4 was 1.73 times lower than in stage T1. Progressive accumulation was detected for P, Pb, and Zn in stage T4. For P, the concentration in stage T4 was 11.1 times higher than in stage T1; for Pb, the concentration in stage T4 was 232.7 times higher than in T1; and for Zn, the concentration in T4 was 8.452 times higher than in T1. This study highlights the marked differences in the concentrations of selected trace metals in different malignant tumor stages. These findings indicate that some trace metals may play important roles in the pathogenesis of RCC.
癌症的发展是一个复杂的多阶段过程，在此过程中，正常细胞会发生基因变化，导致表型改变并获得侵袭其他部位的能力。采用电感耦合等离子体发射光谱法估算健康肾脏和肾细胞癌（RCC）中铝、钙、镉、铬、铜、铁、钾、镁、锰、钠、磷、铅和锌的含量，发现所有元素均存在显著差异。随着恶性疾病的进展，观察到镉和钾含量逐渐降低。事实上，对于镉，T4期的浓度比T1期低263.9倍；对于钾，T4期的浓度比T1期低1.73倍。在T4期检测到磷、铅和锌的逐渐积累。对于磷，T4期的浓度比T1期高11.1倍；对于铅，T4期的浓度比T1期高232.7倍；对于锌，T4期的浓度比T1期高8.452倍。本研究突出了不同恶性肿瘤阶段所选痕量金属浓度的显著差异。这些发现表明，某些痕量金属可能在肾细胞癌的发病机制中发挥重要作用。
