渗透压刺激大鼠后叶加压素 RNA 的起源和调节。

The origin and regulation of posterior pituitary vasopressin ribonucleic Acid in osmotically stimulated rats.

机构信息

Neuroendocrinology Unit, Department of Medicine, Charing Cross and Westminster Medical School, 17 Page Street, London SW1P 2AP, UK.

出版信息

J Neuroendocrinol. 1990 Jun 1;2(3):329-34. doi: 10.1111/j.1365-2826.1990.tb00413.x.

DOI:10.1111/j.1365-2826.1990.tb00413.x

PMID:19215355

Abstract

Abstract Vasopressin ribonucleic acid (VP RNA) accumulates in the posterior lobe of the rat pituitary in response to an osmotic stimulus. The accumulation of posterior pituitary VP RNA can be prevented by stalk transection or the intracerebroventricular injection of colchicine. The hypothalamic and pituitary VP RNAs however, have different structures and are independently regulated. Depletion of serotonin with parachlorophenylalanine blocks the osmotically induced accumulation of both VP and oxytocin RNA in the hypothalamus but does not affect the accumulation of VP RNA in the posterior pituitary gland. In Brattleboro rats, posterior lobe oxytocin RNA but not VP RNA, increases after osmotic stimulation. Although axonal transport of RNA may occur, our results are also consistent with VP RNA synthesis in pituicytes controlled by hypothalamic neuroendocrine factors released by neurohypophyseal terminals in response to osmotic stimuli.

摘要

摘要加压素核糖核酸（VP RNA）在响应渗透刺激时在大鼠垂体后叶中积累。通过切断柄或向脑室内注射秋水仙碱可以防止后叶垂体 VP RNA 的积累。然而，下丘脑和垂体 VP RNAs 具有不同的结构，并且受到独立的调节。用对氯苯丙氨酸耗尽血清素会阻止 VP 和催产素 RNA 在下丘脑的渗透压诱导积累，但不会影响 VP RNA 在垂体后叶中的积累。在 Brattleboro 大鼠中，渗透压刺激后，后叶催产素 RNA 而不是 VP RNA 增加。尽管可能发生 RNA 的轴突运输，但我们的结果也与 VP RNA 在垂体细胞中的合成一致，该合成受神经垂体末端释放的下丘脑神经内分泌因子控制，以响应渗透刺激。