The Medical Unit, The Royal Sussex County Hospital, Brighton, Sussex, UK.
J Neuroendocrinol. 1990 Aug 1;2(4):429-32. doi: 10.1111/j.1365-2826.1990.tb00428.x.
Abstract Pyridostigmine, an acetylcholinesterase inhibitor, stimulates growth hormone (GH) release and is thought to act by inhibiting hypothalamic somatostatin release. There are few data concerning the effect of pyridostigmine on other pituitary hormones apart from GH. We have studied the effect of pyridostigmine on basal GH, thyrotrophin (TSH), prolactin, adrenocorticotrophin and cortisol release, and thyrotrophin-releasing hormone (TRH)-stimulated TSH and prolactin release, in two studies involving nine healthy male subjects. Pyridostigmine stimulated GH release in all subjects but had no effect on adrenocortocotrophin or cortisol levels, or basal or TRH-stimulated TSH and prolactin levels. There are some data to suggest that somatostatin inhibits TRH-stimulated TSH release. Our findings, however, suggest that either endogenous somatostatin tone has little effect on the TSH response to TRH compared to its effects on GH or pyridostigmine acts through a mechanism other than altering somatostatin tone. Pyridostigmine did not alter adrenocorticotrophin or cortisol levels in the presence of a clear action on GH release, providing further evidence that the previously reported effects of cholinergic drugs on cortisol release are stress-related.
摘要 吡啶斯的明是一种乙酰胆碱酯酶抑制剂，它通过抑制下丘脑生长抑素的释放来刺激生长激素 (GH) 的释放。除了 GH 之外，关于吡啶斯的明对其他垂体激素的影响的数据很少。我们研究了吡啶斯的明对基础 GH、促甲状腺素 (TSH)、催乳素、促肾上腺皮质激素和皮质醇释放以及促甲状腺素释放激素 (TRH) 刺激 TSH 和催乳素释放的影响，涉及两项研究，共有 9 名健康男性受试者参与。吡啶斯的明刺激了所有受试者的 GH 释放，但对促肾上腺皮质激素或皮质醇水平、基础或 TRH 刺激的 TSH 和催乳素水平没有影响。有一些数据表明生长抑素抑制 TRH 刺激的 TSH 释放。然而，我们的发现表明，与对 GH 的影响相比，内源性生长抑素对 TSH 对 TRH 的反应的影响较小，或者吡啶斯的明通过改变生长抑素张力以外的机制发挥作用。吡啶斯的明在明显作用于 GH 释放的情况下没有改变促肾上腺皮质激素或皮质醇水平，这进一步证明了先前报道的胆碱能药物对皮质醇释放的影响与应激有关。
