El Hage W, Powell J F, Surguladze S A
Psychol Med. 2009 Sep;39(9):1407-11. doi: 10.1017/S0033291709005236.
Vulnerability to depression has been linked to the interaction of genetic predisposition with stressful life events. This review considers the associations between serotonergic and hypothalamic-pituitary-adrenal (HPA) systems. We follow the standpoint of a previous Editorial Review (Bhagwagar & Cowen, Psychological Medicine 2008, 38, 307-313) and consider another possible mechanism of vulnerability to depressive disorder, that is we suggest that the gene x environment interaction involves complex participation of serotonergic genes modulating response to stress through the HPA system.
抑郁症易感性与遗传易感性和应激性生活事件的相互作用有关。本综述探讨了血清素能系统与下丘脑 - 垂体 - 肾上腺（HPA）系统之间的关联。我们遵循之前一篇社论综述（Bhagwagar和Cowen，《心理医学》2008年，38卷，307 - 313页）的观点，考虑抑郁症易感性的另一种可能机制，即我们认为基因与环境的相互作用涉及血清素能基因通过HPA系统调节对应激反应的复杂参与。
