Schurz B, Schön H J, Wenzl R, Kubista E, Spona J, Huber J, Weindlmayr-Goettel M
First Department of Gynaecology and Obstetrics, University of Vienna, Austria.
Maturitas. 1991 Jun;13(2):123-8. doi: 10.1016/0378-5122(91)90095-8.
Breast cyst fluid (BCF) and plasma levels of beta-endorphin (beta-EP), oestradiol (E2), progesterone (P), luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid-stimulating hormone (TSH), prolactin (PRL) and cortisol were assayed radiochemically in a group of 10 premenopausal women aged 45-50 years suffering from gross cystic breast disease. The concentration of beta-EP (fmol/ml) in BCF (17.6 +/- 4.6 S.E.) was over four times higher than that in plasma (4.2 +/- 0.5 S.E.). The level of E2 was 41 times higher (1738.2 +/- 350.5 S.E. pg/ml) and that of P was 47 times higher (65.47 +/- 8.25 S.E. ng/ml) in BCF than in plasma. The significantly increased values of beta-EP, E2 and P in BCF and the identification of beta-EP in the cyst-lining epithelium indicated that local synthesis occurs. Growth factor-like properties of beta-EP and E2 are responsible for the propagation of cystic changes. The autonomous formation and activity of beta-EP, E2 and P in cystic formations were not correlated with LH, FSH, TSH and cortisol levels, which were significantly higher in plasma than in BCF. The concentration of PRL in BCF was not significantly higher than that in plasma. Moreover, the plasma concentrations of testosterone, androstenedione, thyroxine, triiodothyronine, thyroxine-binding globulin and sex-hormone-binding globulin were within the normal ranges. In this study we demonstrated synergism between beta-EP and steroid hormones which encourages the development of gross cystic disease in premenopausal women.
对10名年龄在45至50岁之间患有严重囊性乳腺病的绝经前女性，采用放射化学法测定了其乳腺囊肿液（BCF）和血浆中β-内啡肽（β-EP）、雌二醇（E2）、孕酮（P）、促黄体生成素（LH）、促卵泡激素（FSH）、促甲状腺激素（TSH）、催乳素（PRL）和皮质醇的水平。BCF中β-EP的浓度（飞摩尔/毫升，17.6±4.6标准误）比血浆中（4.2±0.5标准误）高四倍多。BCF中E2的水平比血浆中高41倍（1738.2±350.5标准误皮克/毫升），P的水平比血浆中高47倍（65.47±8.25标准误纳克/毫升）。BCF中β-EP、E2和P值显著升高，且在囊肿内衬上皮中鉴定出β-EP，表明存在局部合成。β-EP和E2的生长因子样特性是囊性变化传播的原因。囊性结构中β-EP、E2和P的自主形成和活性与LH、FSH、TSH和皮质醇水平无关，这些激素在血浆中的水平显著高于BCF。BCF中PRL的浓度并不显著高于血浆中的浓度。此外，血浆中睾酮、雄烯二酮、甲状腺素、三碘甲状腺原氨酸、甲状腺素结合球蛋白和性激素结合球蛋白的浓度均在正常范围内。在本研究中，我们证明了β-EP与甾体激素之间的协同作用，这种作用促进了绝经前女性严重囊性疾病的发展。
