De Val Sarah, Black Brian L
Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, 94158, USA.
Dev Cell. 2009 Feb;16(2):180-95. doi: 10.1016/j.devcel.2009.01.014.
The transcription factors that regulate endothelial cell development have been a focus of active research for several years, and many players in the endothelial transcriptional program have been identified. This review discusses the function of several major regulators of endothelial transcription, including members of the Sox, Ets, Forkhead, GATA, and Kruppel-like families. This review also highlights recent developments aimed at unraveling the combinatorial mechanisms and transcription factor interactions that regulate endothelial cell specification and differentiation during vasculogenesis and angiogenesis.
调控内皮细胞发育的转录因子多年来一直是活跃的研究焦点,并且在内皮转录程序中的许多关键因子已被识别。本综述讨论了内皮转录的几个主要调节因子的功能,包括Sox、Ets、Forkhead、GATA和Kruppel样家族的成员。本综述还强调了旨在揭示在血管生成和血管新生过程中调控内皮细胞特化和分化的组合机制及转录因子相互作用的最新进展。