Department of Internal Diseases and Cardiological Rehabilitation, Medical University of Lodz, Hallera Sq. 1, 90-647 Lodz, Poland.
Arch Gerontol Geriatr. 2010 Jan-Feb;50(1):114-8. doi: 10.1016/j.archger.2008.12.012. Epub 2009 Feb 13.
Cardiovascular morbidity is the leading cause of mortality in the developed nations. Elevated serum cholesterol is a major risk factor for ischemic heart disease, one of the common cardiovascular morbidity in older adults, statins have been shown to be effective in reducing serum cholesterol and improving outcomes. Hypercholesterolemia is common in older adults and is one of the major modifiable risk factors. Yet, these patients have often been excluded from major clinical trials of statins and evidence suggests of their underuse. Data from recent clinical trials of statins indicate that the elderly patients with the highest cardiovascular risk are likely to derive the most benefits from cholesterol lowering. With the aging of the population, the prevalence of hypercholesterolemia and cardiovascular morbidity is likely to increase. In this review we evaluate the evidence for the use of statins in older adults.
心血管疾病是发达国家死亡的主要原因。血清胆固醇升高是缺血性心脏病的主要危险因素之一，缺血性心脏病是老年人常见的心血管疾病之一，他汀类药物已被证明能有效降低血清胆固醇并改善预后。高胆固醇血症在老年人中很常见，是可改变的主要危险因素之一。然而，这些患者经常被排除在他汀类药物的主要临床试验之外，并且有证据表明他们的使用不足。最近他汀类药物临床试验的数据表明，心血管风险最高的老年患者可能从降低胆固醇中获益最大。随着人口老龄化，高胆固醇血症和心血管疾病的患病率可能会增加。在这篇综述中，我们评估了他汀类药物在老年人中的应用证据。
