Freyre A, Fialho C G, Bigatti L E, Araujo F A P, Falcón J D, Mendez J, González M
Laboratorio de Toxoplasmosis, Departamento de Parasitología, Alberto Lasplaces 1550, Montevideo 11600, Uruguay.
Exp Parasitol. 2009 Jun;122(2):140-4. doi: 10.1016/j.exppara.2009.02.004. Epub 2009 Feb 13.
The objective of the research was to test the hamster for a model of transmission of congenital toxoplasmosis. A non-invasive method for the diagnosis of pregnancy in hamsters was designed, with a specificity and a sensitivity of 70.2 and 94.7%, respectively (n=168). Of 32 females with a chronic toxoplasma infection, 3 transmitted Toxoplasma congenitally during their first pregnancy, but not during the subsequent pregnancy. Congenital transmission rates of infections initiated during pregnancy with 2 stages of 2 strains of Toxoplasma were in the range of 33 to 100% of the 76 females inoculated. Only 1 of 17 females transmitted the parasite exclusively via milk. It was concluded that the hamster is a promising species for a model of transmission of congenital toxoplasmosis.
该研究的目的是测试仓鼠作为先天性弓形虫病传播模型的可行性。设计了一种非侵入性的仓鼠妊娠诊断方法，其特异性和敏感性分别为70.2%和94.7%（n = 168）。在32只慢性弓形虫感染的雌性仓鼠中，有3只在首次怀孕时发生了先天性弓形虫传播，但在随后的怀孕中未发生。在76只接种了2株弓形虫2个阶段的怀孕雌性仓鼠中，先天性传播率在33%至100%之间。17只雌性仓鼠中只有1只仅通过乳汁传播了寄生虫。得出的结论是，仓鼠是先天性弓形虫病传播模型的一个有前景的物种。
