Effect of megestrol acetate on serum albumin level in malnourished dialysis patients.

OBJECTIVE

Malnutrition is a common problem in dialysis patients, and may affect up to one third of patients. It is associated with high mortality and morbidity. Although a number of studies were performed to determine effective treatment, there is no proven medication for this condition. This study aimed to evaluate the effect of megestrol acetate (MA) on serum albumin levels in malnourished dialysis patients.

DESIGN

This was a randomized, controlled clinical trial.

SETTING

The setting, a dialysis center at Razi Hospital, Rasht, Iran, provides services to dialysis patients.

PATIENTS

Twenty-two malnourished dialysis patients with persistent hypoalbuminemia (albumin, <3.5 g/dL for 2 months) participated, and were randomly assigned to either an experimental group or a control group.

INTERVENTION

The experimental group was treated with MA, 40 mg twice daily, over 2 months, and was compared with the control group. The collected data were analyzed using SPSS (version 10; Chicago, IL).

RESULTS

After 2 months, the mean (+/-SD) serum albumin level in the experimental group rose from 3.31 +/- 0.31 g/dL to 4.41 +/- 0.31 g/dL, but in the control group, it declined, from 3.35 +/- 0.21 to 3.02 +/- 0.48 g/dL. The difference between the two groups was significant (P = .002).

CONCLUSION

At a dose of 40 mg twice a day, MA safely increased serum albumin in malnourished dialysis patients.