[TBX3 mRNA的表达及其在乳腺癌发病机制和转移中的作用]
[Expression of TBX3 mRNA and its role in the pathogenesis and metastasis of breast cancer].
作者信息
Chen Zhong-hua, Lü Guang-ming, Ji Tian-hai
机构信息
Fuzhou General Hospital of Nanjing Command, Fuzhou 350025, China.
出版信息
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jan;29(1):87-9.
OBJECTIVE
To explore the role of TBX3 gene in the pathogenesis of breast cancer.
METHODS
The total RNA of 51 fresh breast cancer tissues and the corresponding adjacent tissues were extracted and reverse transcribed into cDNA to detect the expression of TBX3 mRNA by real-time PCR. The correlation between TBX3 mRNA expression and the clinicopathologic parameters in relation to breast cancer metastasis was analyzed.
RESULT
Compared to that in the adjacent tissues, the expression of TBX3 mRNA was markedly increased in breast cancer tissues. TBX3 mRNA expression was significantly higher in metastatic breast cancer than in non-metastatic tumors.
CONCLUSION
Increased expression of TBX3 mRNA suggests the involvement of TBX3 in the pathogenesis and metastasis of breast cancer.
目的
探讨TBX3基因在乳腺癌发病机制中的作用。
方法
提取51例新鲜乳腺癌组织及其相应癌旁组织的总RNA，逆转录成cDNA，采用实时荧光定量PCR检测TBX3 mRNA的表达。分析TBX3 mRNA表达与乳腺癌转移相关临床病理参数之间的相关性。
结果
与癌旁组织相比，乳腺癌组织中TBX3 mRNA的表达明显增加。转移性乳腺癌中TBX3 mRNA的表达明显高于非转移性肿瘤。
结论
TBX3 mRNA表达增加提示TBX3参与乳腺癌的发病机制和转移。
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