Leibowitz H M, Kupferman A
Arch Ophthalmol. 1977 Apr;95(4):682-5. doi: 10.1001/archopht.1977.04450040148023.
Concurrent instillation of individual preparations of a corticosteroid and an antibiotic resulted in significantly (P less than .05) lower peak corneal and aqueous humor steroid levels than those achieved by the steroid alone. Both the interval elapsing between instillation of the two drugs and the sequence in which they were administered influenced subsequent steroid bioavailability. Corticosteroid levels in the cornea after administration of a combination steroid-antibiotic preparation were not significantly different (P less than .05) from those detected after instillation of the same steroid alone, suggesting that, for the treatment of corneal disorders, use of a combination preparation may offer a method to circumvent certain drug interactions. The decrease in ocular steroid bioavailability could not be directly equated with differences in antinflammatory effectiveness, so that the therapeutic relevance of the demonstrated drug interaction is not known.
同时滴注皮质类固醇和抗生素的单独制剂，导致角膜和房水类固醇峰值水平显著低于单独使用类固醇时的水平（P<0.05）。两种药物滴注之间的时间间隔以及给药顺序都会影响随后的类固醇生物利用度。联合使用类固醇-抗生素制剂给药后角膜中的皮质类固醇水平与单独滴注相同类固醇后检测到的水平无显著差异（P<0.05），这表明，对于角膜疾病的治疗，使用联合制剂可能提供一种规避某些药物相互作用的方法。眼内类固醇生物利用度的降低不能直接等同于抗炎效果的差异，因此所证明的药物相互作用的治疗相关性尚不清楚。
