Leibowitz H M
Ophthalmology. 1980 Aug;87(8):753-8. doi: 10.1016/s0161-6420(80)35174-9.
The ability of the cornea to react to inflammatory stimuli is limited, and in most instances the polymorphonuclear leukocyte is primarily responsible for corneal damage. Of currently available drugs, corticosteroids are the most effective for the non-specific control of these inflammatory cells. Principles for obtaining maximal therapeutic effect from minimal amounts of the drug are presented. The use of corticosteroids in the treatment of a keratitis caused by various types of replicating microbial agents is discussed. The response to therapy of inflammatory processes in the conjunctiva seemingly differs from the response in the cornea. Suggestions are offered for corticosteroid use in conjunctivitis.
角膜对炎症刺激的反应能力有限，在大多数情况下，多形核白细胞是造成角膜损伤的主要原因。在目前可用的药物中，皮质类固醇对这些炎症细胞的非特异性控制最为有效。本文介绍了从最小剂量药物中获得最大治疗效果的原则。讨论了皮质类固醇在治疗由各种类型的复制性微生物病原体引起的角膜炎中的应用。结膜炎症过程对治疗的反应似乎与角膜不同。文中还给出了在结膜炎中使用皮质类固醇的建议。
