Blyakhman Felix A, Naidich Anna M, Kolchanova Svetlana G, Sokolov Sergey Yu, Kremleva Yulia V, Chestukhin Vasily V
Department of Biomedical Physics, Ural State Medical Academy, 3 Repin Str., Ekaterinburg 620219, Russia.
Eur J Echocardiogr. 2009 Jul;10(5):613-8. doi: 10.1093/ejechocard/jep010. Epub 2009 Feb 13.
The goal of this study was to test whether peculiarities of left ventricular (LV) regional function place limits on the validity of ejection fraction (EF) as a measure of the myocardial functional state.
Transthoracic and transoesophageal data from patients with a variety of cardiac conditions were used for analysis of LV regional function. The focus was on the effects of mechanical asynchrony. Ejection fraction was calculated on the basis of LV end-diastolic volume and end-systolic volume obtained by two different ways: (i) end-systolic volume as a whole; and (ii) the sum of all regional end-systolic volumes (which may occur at different times). The relative difference, D-EF, between EFs obtained by (i) and (ii) was taken as the 'merit' of EF. A value of zero is the highest merit. Irrespective of the examination method, we found that D-EF was always higher than zero, and that its value depended on the extent of mechanical asynchrony.
Ejection fraction is not the arithmetic average of regional EFs. An increase of asynchrony increases D-EF, i.e. it reduces the merit of EF as a measure of cardiac function.
本研究的目的是检验左心室（LV）区域功能的特殊性是否限制了射血分数（EF）作为心肌功能状态指标的有效性。
来自患有各种心脏疾病患者的经胸和经食管数据用于分析左心室区域功能。重点是机械不同步的影响。射血分数是根据通过两种不同方式获得的左心室舒张末期容积和收缩末期容积计算得出的：（i）整体收缩末期容积；以及（ii）所有区域收缩末期容积之和（可能在不同时间出现）。通过（i）和（ii）获得的射血分数之间的相对差异D-EF被视为EF的“优点”。零值是最高优点。无论检查方法如何，我们发现D-EF总是高于零，并且其值取决于机械不同步的程度。
射血分数不是区域射血分数的算术平均值。不同步性的增加会增加D-EF，即它会降低EF作为心脏功能指标的优点。
