Domagala-Kulawik J, Maskey-Warzechowska M, Krenke R, Chazan R
Department of Pneumology and Allergology, Warsaw Medical University, Warsaw, Poland.
J Physiol Pharmacol. 2008 Dec;59 Suppl 6:243-51.
Some of interstitial lung diseases have a potential relation to tobacco smoking and are known as smoking-related interstitial lung diseases (sr-ILD). The aim of this study was to present the typical features in bronchoalveolar lavage fluid (BALF) of patients with sr-ILD with special account to the morphology of alveolar macrophages. We have found typical features of sr-LD in 18 patients with interstitial lung disease. All patients were smokers. Pulmonary function was moderately impaired. Control group consisted of 12 asymptomatic smokers and 18 healthy nonsmokers. The median total cell count in BALF of patients with desquamative interstitial pneumonia was 64.5 x 10(6) and was much higher than in asymptomatic smokers--9.0 x 10(6), and healthy nonsmokers--3.25 x 10(6). A high proportion (mean 90%) and number (55.5 x 10(6)) of macrophages with the predominance of pigmented cells was found. Mean proportion of CD14 positive macrophages was 6%, and of CD54 positive macrophages - 62%. We concluded that features in BALF typical for sr-ILD are uncommon among routinely evaluated specimens, but differ markedly from other forms of ILD.
一些间质性肺疾病与吸烟存在潜在关联，被称为吸烟相关间质性肺疾病（sr - ILD）。本研究的目的是阐述sr - ILD患者支气管肺泡灌洗（BALF）液的典型特征，特别关注肺泡巨噬细胞的形态。我们在18例间质性肺疾病患者中发现了sr - LD的典型特征。所有患者均为吸烟者。肺功能有中度受损。对照组由12名无症状吸烟者和18名健康非吸烟者组成。脱屑性间质性肺炎患者BALF中的细胞总数中位数为64.5×10⁶，远高于无症状吸烟者的9.0×10⁶和健康非吸烟者的3.25×10⁶。发现高比例（平均90%）且数量众多（55.5×10⁶）的巨噬细胞，其中色素沉着细胞占优势。CD14阳性巨噬细胞的平均比例为6%，CD54阳性巨噬细胞的平均比例为62%。我们得出结论，sr - ILD在BALF中的典型特征在常规评估样本中并不常见，但与其他形式的ILD有显著差异。
