Boyer A L, Desobry G E, Wells N H
Department of Radiation Physics, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Med Phys. 1991 Jul-Aug;18(4):703-12. doi: 10.1118/1.596663.
A treatment planning methodology was developed to investigate the invariant kernel form of conformal therapy proposed by Brahme. Three-dimensional dose distributions were calculated by convolving a rotationally symmetric, invariant kernel with weighting distributions. Fourier transform convolution techniques implemented on an array processor were used to achieve high calculation speeds, thereby allowing iterative techniques in the spatial and frequency domains for computing dose distributions that asymptotically approach a desired dose distribution. To use rotationally symmetric kernels, the generality of the solution is traded for a fast, deterministic, inverse planning approach. The limitations imposed on the dose distributions by this loss of generality are characterized and tentative conclusions are drawn about the potentials and limits of clinical application of this form of the methodology. Further developments of the concept are suggested.
开发了一种治疗计划方法，以研究布拉赫姆提出的适形治疗的不变核形式。通过将旋转对称的不变核与权重分布进行卷积来计算三维剂量分布。在阵列处理器上实现的傅里叶变换卷积技术用于实现高计算速度，从而允许在空间和频域中使用迭代技术来计算渐近接近所需剂量分布的剂量分布。为了使用旋转对称核，用一种快速、确定性的逆向计划方法换取了解的一般性。表征了由于这种一般性丧失而对剂量分布施加的限制，并对这种形式的方法在临床应用中的潜力和局限性得出了初步结论。还提出了该概念的进一步发展方向。
