Howman R A, Barr A L, Shand A W, Dickinson J E
Haematology Department, University of Western Australia, King Edward Memorial Hospital, Subiaco, WA, Australia.
Fetal Diagn Ther. 2009;25(1):93-7. doi: 10.1159/000202171. Epub 2009 Feb 14.
Immune thrombocytopenic purpura (ITP) may complicate pregnancy and, uncommonly, may cause severe neonatal thrombocytopenia. However, it is difficult to predict which neonates are at risk of severe thrombocytopenia. Direct fetal sampling is not commonly done, as it poses significant risks to the fetus. Furthermore, appropriate antenatal treatment of neonates is controversial. We describe the case of a 32-year-old woman with chronic severe ITP and a previous severely affected infant, pregnant with trichorionic triplets, who was successfully managed with the use of weekly intravenous immunoglobulin 1 g/kg without recourse to direct fetal sampling.
免疫性血小板减少性紫癜（ITP）可能使妊娠复杂化，并且罕见情况下可能导致严重的新生儿血小板减少症。然而，很难预测哪些新生儿有严重血小板减少症的风险。由于直接胎儿取样对胎儿有重大风险，所以并不常用。此外，对新生儿进行适当的产前治疗存在争议。我们描述了一名32岁患有慢性重度ITP且之前有过严重患病婴儿的女性病例，她怀着三绒毛膜三胞胎，通过每周静脉注射1 g/kg免疫球蛋白成功进行了治疗，而无需进行直接胎儿取样。
