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[原发性甲状旁腺功能亢进的治疗实践]

[Treatment practice in primary hyperparathyroidism].

作者信息

Lindekleiv Haakon M, Due Jan, Svartberg Johan, Varhaug Jan Erik

机构信息

Avdeling for urologi og endokrin kirurgi, Universitetssykehuset Nord-Norge, 9038 Tromsø.

出版信息

Tidsskr Nor Laegeforen. 2009 Feb 12;129(4):300-2. doi: 10.4045/tidsskr.09.34210.

Abstract

BACKGROUND

A recent study found considerable regional differences in treatment of primary hyperparathyroidism in Norway. There is no consensus on specific indications for operation in these patients. We surveyed opinions among Norwegian endocrine surgeons and endocrinologists on the indications for surgical treatment of primary hyperparathyroidism.

MATERIAL AND METHODS

A questionnaire on preoperative evaluation, indications for surgery and treatment of patients with primary hyperparathyroidism was sent to the chief consultants of surgical departments that operated on parathyroid glands in 2005. The questionnaire was also sent to endocrinologists at the same hospitals.

RESULTS

In 2006, 415 parathyroid gland operations were performed in 17 Norwegian hospitals, with a median of 18 operations per hospital. A total of 46 surgeons operated on the parathyroid glands, with a median of two surgeons per hospital. Hospitals differed with respect to preoperative evaluations and indications for operative treatment; but these differences did not coincide with regional differences in the frequency of parathyroid surgery. There was a good correlation between endocrine surgeons and endocrinologists on the indications for surgery in primary hyperparathyroidism, but neither group adhered unconditionally to the international guidelines for surgical treatment of patients with primary hyperparathyroidism. Patients in the hospitals that operated most frequently were initially diagnosed in a surgical department.

INTERPRETATION

Our survey did not reveal differences that could explain the large regional variations in the frequency of parathyroid surgery.

摘要

背景

最近一项研究发现,挪威原发性甲状旁腺功能亢进症的治疗存在显著的地区差异。对于这些患者手术的具体指征尚无共识。我们调查了挪威内分泌外科医生和内分泌学家对原发性甲状旁腺功能亢进症手术治疗指征的看法。

材料与方法

一份关于原发性甲状旁腺功能亢进症患者术前评估、手术指征和治疗的问卷被发送给了2005年进行甲状旁腺手术的外科科室的主任顾问。该问卷也被发送给了同一家医院的内分泌学家。

结果

2006年,挪威17家医院共进行了415例甲状旁腺手术,每家医院手术中位数为18例。共有46名外科医生进行了甲状旁腺手术,每家医院外科医生中位数为2名。各医院在术前评估和手术治疗指征方面存在差异;但这些差异与甲状旁腺手术频率的地区差异并不一致。内分泌外科医生和内分泌学家在原发性甲状旁腺功能亢进症手术指征方面具有良好的相关性,但两组均未无条件遵循原发性甲状旁腺功能亢进症患者手术治疗的国际指南。手术频率最高的医院的患者最初是在外科科室确诊的。

解读

我们的调查未发现能够解释甲状旁腺手术频率地区差异巨大的不同之处。

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