（±）-帕拉维西诺内酯A的仿生全合成

Biomimetic total synthesis of (+/-)-pallavicinolide A.

作者信息

Dong Jia-Qiang, Wong Henry N C

机构信息

Department of Chemistry, Centre of Novel Functional Molecules, Institute of Chinese Medicine and Institute of Molecular Technology for Drug Discovery and Synthesis, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China.

出版信息

Angew Chem Int Ed Engl. 2009;48(13):2351-4. doi: 10.1002/anie.200806335.

DOI:10.1002/anie.200806335

PMID:19219887

Abstract

Piecing it together: The first total synthesis of naturally occurring diterpene pallavicinolide A was achieved. Notable features are highlighted by three key biomimetic transformations: a base-promoted Grob fragmentation, a singlet oxygen oxidation, and an intramolecular Diels-Alder cycloaddition.

摘要