Bennett Maxwell R
Department of Physiology, University of Sydney, Sydney, NSW.
Med J Aust. 2009 Feb 16;190(S4):S14-6. doi: 10.5694/j.1326-5377.2009.tb02368.x.
During adolescence, about 30% of the synapses formed during childhood in the dorsolateral prefrontal cortex (DLPC) are lost; in patients with schizophrenia, the synapse loss is about 60%. Studies of synapse loss in the neuromuscular junction have provided insights into the molecular basis of synapse formation and regression, thereby providing a paradigm for investigations of synapse loss in the DLPC. Research into some of these molecules in the DLPC has shown that they are crucial to synapse formation and regression. Further research in this field could examine when synapse loss in the DLPC of patients with schizophrenia occurs, and further elucidate how these molecules are involved in the development of schizophrenia.
在青春期，儿童期在背外侧前额叶皮质（DLPC）形成的突触约有30%会消失；而在精神分裂症患者中，突触损失约为60%。对神经肌肉接头处突触损失的研究为突触形成和消退的分子基础提供了见解，从而为研究DLPC中的突触损失提供了一个范例。对DLPC中其中一些分子的研究表明，它们对突触的形成和消退至关重要。该领域的进一步研究可以考察精神分裂症患者DLPC中的突触损失何时发生，并进一步阐明这些分子如何参与精神分裂症的发展。
