Gassmueller Johannes, Rowold Elisabeth, Frase Thomas, Hughes-Formella Betsy
bioskin GmbH, Burchardstrasse 17, D-20095 Hamburg, Germany.
Eur J Dermatol. 2009 May-Jun;19(3):224-31. doi: 10.1684/ejd.2009.0640. Epub 2009 Feb 17.
There is a need for a simple and reliable tool to evaluate hair loss and treatment effects in patients suffering from alopecia. In 2001 TrichoScan was introduced as a fully-automated method for the measurement of biological parameters of hair growth such as density, diameter and growth rate. However, the conventional phototrichogram method with manual marking of hairs on images is still performed and, although no real independent side-by-side comparison is available, the manual method is sometimes defined as the most precise method of measurement. The aim of this study was validation of the Trichoscan method by comparative assessment of TrichoScan analysis and manual marking of hairs. Digital images were taken from 10 patients with androgenetic alopecia (AGA) and validity and reliability of both methods were assessed. This study showed an excellent correlation of TrichoScan and manual marking of hairs. Considerable variability was noted in the results from manually evaluated images (range 2.71%-12.95%), compared to none in TrichoScan analyzed images. Results with TrichoScan were obtained more quickly and were more reproducible with a smaller margin of operator error. The consistency in the Trichoscan data allows statistically significant results to be obtained with a smaller sample size.
需要一种简单可靠的工具来评估脱发患者的脱发情况和治疗效果。2001年，TrichoScan作为一种用于测量毛发生长生物学参数（如密度、直径和生长速率）的全自动方法被引入。然而，传统的在图像上手动标记毛发的毛发照片测量法仍在使用，并且尽管没有真正独立的并列比较，但手动方法有时被定义为最精确的测量方法。本研究的目的是通过对TrichoScan分析和毛发手动标记的比较评估来验证TrichoScan方法。从10名雄激素性脱发（AGA）患者获取数字图像，并评估两种方法的有效性和可靠性。本研究显示TrichoScan与毛发手动标记具有极好的相关性。与TrichoScan分析图像结果无变异性相比，手动评估图像结果存在相当大的变异性（范围为2.71%-12.95%）。使用TrichoScan获得结果更快，且具有更小的操作者误差范围，重复性更高。TrichoScan数据的一致性使得用较小样本量就能获得具有统计学意义的结果。
