Hoffmann R
Universitäts-Hautklinik, Marburg, Germany.
Hautarzt. 2002 Dec;53(12):798-804. doi: 10.1007/s00105-002-0421-1.
BACKGROUND/OBJECTIVE: Hair loss or hair thinning is a common complaint in clinical dermatology. Patients seeking advice for hair loss are not necessarily bald. In addition, the effects of therapy are hard to measure. Consequently, there is a need for a sensitive tool to monitor hair loss and treatment response. Such a method must be able to analyze the biological parameters of hair growth, which are: 1: hair density (n/cm(2)), 2: hair diameter (micrometer), 3: hair growth rate (mm/day) and 4: anagen/telogen ratio.
PATIENTS/METHODS: We present the TrichoScan as a method which combines epiluminescence microscopy (ELM) with automatic digital image analysis for the measurement of human, and potentially animal hair, in situ. The TrichoScan is able to analyze all biological parameters of hair growth with a so called intraclass correlation of approximately 91% within the same operator and an intraclass correlation of approximately 97% for different operators.
The application of the technique is demonstrated by comparison of the hair parameters in individuals without apparent hair loss with men with untreated AGA and men after treatment with finasteride (1 mg/day), and women who were treated with minoxidil. We were able to detect a significant increase in hair counts and cumulative hair thickness 3 and 6 months after treatment.
The advantage of the TrichoScan is that it can be used for clinical studies to compare placebo versus treatment or to compare different hair growth promoting substances, it can be used for studying AGA or other forms of diffuse hair loss, and it can be adopted to study the effect of drugs or laser treatment on hypertrichosis or hirsutism.
背景/目的：脱发或头发稀疏是临床皮肤科常见的主诉。寻求脱发建议的患者不一定是秃头。此外，治疗效果难以衡量。因此，需要一种灵敏的工具来监测脱发情况和治疗反应。这样一种方法必须能够分析头发生长的生物学参数，这些参数包括：1. 头发密度（根/平方厘米），2. 头发直径（微米），3. 头发生长速度（毫米/天）以及4. 生长期/休止期比例。
患者/方法：我们介绍了毛发扫描仪（TrichoScan），这是一种将落射荧光显微镜（ELM）与自动数字图像分析相结合的方法，用于在原位测量人类乃至潜在动物的毛发。毛发扫描仪能够分析头发生长的所有生物学参数，在同一操作人员内的组内相关系数约为91%，不同操作人员之间的组内相关系数约为97%。
通过比较无明显脱发个体、未经治疗的雄激素性脱发男性、服用非那雄胺（1毫克/天）治疗后的男性以及使用米诺地尔治疗的女性的头发参数，展示了该技术的应用。我们能够检测到治疗3个月和6个月后头发数量和累积头发厚度显著增加。
毛发扫描仪的优势在于它可用于临床研究，以比较安慰剂与治疗效果，或比较不同的促进头发生长物质；可用于研究雄激素性脱发或其他形式的弥漫性脱发；还可用于研究药物或激光治疗对多毛症或毛发过多的影响。
