Morís-De la Tassa G, Arias-Rodríguez M
Sección de Neurología, Hospital San Agustín, Camino de Heros, 4. E-33400 Avilés, Asturias, España,
Rev Neurol. 2009 Jan 23;48 Suppl 1:S27-31.
The physiopathology of the motor symptoms is the best known aspect of the Parkinson's disease. This knowledge led us to use several drugs and therapeutic strategies to improve these features of the Parkinson's disease.
Mainly based in the theory of continuous dopaminergic stimulation, new drugs, new routes of administration and new galenic formulations have been developed, as well surgical procedures and other therapies have been introduced to improve the management of patients with long diseases without a responses to the classic therapies. At the same time, several often-used drugs have disappeared due to its non-parkinsonian adverse effects and also the influence in quality of life of non-motor parkinsonian adverse effects have been ultimately recognized.
运动症状的生理病理学是帕金森病最广为人知的方面。这一认知促使我们使用多种药物和治疗策略来改善帕金森病的这些特征。
主要基于持续多巴胺能刺激理论，已研发出新药、新给药途径和新剂型，同时也引入了手术程序及其他疗法，以改善病程较长且对经典疗法无反应的患者的治疗管理。与此同时，几种常用药物因非帕金森病不良反应而不再使用，并且非运动性帕金森病不良反应对生活质量的影响最终也得到了认识。
