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犬种的遗传多样性:比较系谱数据和分子数据的品种内多样性

Genetic diversity of dog breeds: within-breed diversity comparing genealogical and molecular data.

作者信息

Leroy G, Verrier E, Meriaux J C, Rognon X

机构信息

AgroParisTech, UMR1236 Génétique et Diversité Animales, Paris, France.

出版信息

Anim Genet. 2009 Jun;40(3):323-32. doi: 10.1111/j.1365-2052.2008.01842.x. Epub 2009 Feb 16.

Abstract

The genetic diversity of 61 dog breeds raised in France was investigated. Genealogical analyses were performed on the pedigree file of the French kennel club. A total of 1514 dogs were also genotyped using 21 microsatellite markers. For animals born from 2001 to 2005, the average coefficient of inbreeding ranged from 0.2% to 8.8% and the effective number of ancestors ranged from 9 to 209, according to the breed. The mean value of heterozygosity was 0.62 over all breeds (range 0.37-0.77). At the breed level, few correlations were found between genealogical and molecular parameters. Kinship coefficients and individual similarity estimators were, however, significantly correlated, with the best mean correlation being found for the Lynch & Ritland estimator (r = 0.43). According to both approaches, it was concluded that special efforts should be made to maintain diversity for three breeds, namely the Berger des Pyrénées, Braque Saint-Germain and Bull Terrier.

摘要

对法国饲养的61个犬种的遗传多样性进行了调查。对法国养犬俱乐部的系谱文件进行了系谱分析。还使用21个微卫星标记对总共1514只狗进行了基因分型。对于2001年至2005年出生的动物,根据品种不同,平均近亲繁殖系数在0.2%至8.8%之间,有效祖先数量在9至209之间。所有品种的杂合度平均值为0.62(范围为0.37 - 0.77)。在品种层面,系谱参数和分子参数之间几乎没有相关性。然而,亲缘系数和个体相似性估计值显著相关,Lynch & Ritland估计值的平均相关性最佳(r = 0.43)。根据这两种方法得出结论,应特别努力维持三个品种的多样性,即比利牛斯牧羊犬、圣日耳曼指示犬和牛头梗。

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