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慢性肾脏病中的贫血和矿物质骨病:当前文献综述及对临床护理实践的启示

Anaemia and mineral bone disorder in chronic kidney disease: a review of the current literature and implications for clinical nursing practice.

作者信息

Limrick Claire, McNichols-Thomas Coral

机构信息

Oxford Kidney Unit, Churchill Hospital, Old Road Headington, Oxford OX3 7LJ, UK.

出版信息

J Ren Care. 2009 Mar;35 Suppl 1:94-100. doi: 10.1111/j.1755-6686.2009.00062.x.

Abstract

Secondary hyperparathyroidism (SHPT) is one of the factors reported to have a negative impact on anaemia of chronic kidney disease (ACKD) and its treatment. SHPT is one of the abnormalities resulting from altered bone mineral metabolism. Five possible mechanisms have been proposed as to how SHPT impacts on anaemia in this paper. Each of these mechanisms will be considered and the treatment options reviewed including the implications for erythropoietic stimulating agents (ESA) prescribing. Anaemia and SHPT are both strongly predictive of complications and death from cardiovascular events in patients with chronic kidney disease (CKD). Nursing care of this group of patients should, therefore, be holistic in order to ensure optimum management. Ways in which we can practice to enhance quality of life and outcomes in this patient population will be discussed.

摘要

继发性甲状旁腺功能亢进(SHPT)是据报道对慢性肾脏病贫血(ACKD)及其治疗有负面影响的因素之一。SHPT是骨矿物质代谢改变导致的异常之一。本文就SHPT如何影响贫血提出了五种可能的机制。将对每种机制进行探讨,并回顾治疗选择,包括对促红细胞生成素(ESA)处方的影响。贫血和SHPT都是慢性肾脏病(CKD)患者发生心血管事件并发症和死亡的强烈预测因素。因此,对这组患者的护理应是全面的,以确保最佳管理。将讨论我们可以采取哪些方法来提高这一患者群体的生活质量和治疗效果。

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