Madden D R, Gorga J C, Strominger J L, Wiley D C
Committee on Higher Degrees in Biophysics, Harvard University, Cambridge, Massachusetts.
Nature. 1991 Sep 26;353(6342):321-5. doi: 10.1038/353321a0.
X-ray crystallography reveals electron density in the antigen-binding site of HLA-B27 that is an interpretable image of nonameric peptides in a largely extended conformation. Clear density exists for the main chain and several side chains and is consistent with the sequence of 11 nonameric self-peptides eluted from HLA-B27. Pockets in the antigen-binding cleft bind four side chains and the amino and carboxyl termini of the peptide.
X射线晶体学揭示了HLA - B27抗原结合位点的电子密度，这是处于大致伸展构象的九聚体肽的可解释图像。主链和几个侧链存在清晰的密度，并且与从HLA - B27洗脱的11种九聚体自身肽的序列一致。抗原结合裂隙中的口袋结合肽的四个侧链以及氨基和羧基末端。
