Langenbecks Arch Surg. 2010 Aug;395(6):713-8. doi: 10.1007/s00423-009-0471-2. Epub 2009 Feb 18.
We aimed to investigate the effect of sildenafil on the healing process of abdominal wall wound in rats.
The study was performed with adult female Wistar-Albino rats. Control group (n = 50) were fed on standard laboratory diet until 12 h before surgery. Study group (n = 50) were applied orally with orogastric tube 10 mg/kg once a day for 10 days of sildenafil therapy. Each rat was anesthetized, and a 4-cm-long midline laparotomy was performed. Ten animals from each group were killed at postoperative days (PODs) 4, 7, 14, 21, and 35. Breaking strength analysis was measured, and the abdominal incision wounds were examined histologically.
Breaking strength for the midline incision, acute inflammation score on POD 14, and neovascularization on PODs 7, 14, 21, and 35 were significantly higher in the study group.
Sildenafil can be used as a supporting factor in wound healing.
本研究旨在探讨西地那非对大鼠腹壁切口愈合过程的影响。
本研究采用成年雌性 Wistar-Albino 大鼠进行。对照组（n = 50）在术前 12 小时前给予标准实验室饮食。研究组（n = 50）给予口服管饲西地那非 10mg/kg，每天一次，共 10 天。每只大鼠均接受全身麻醉，并进行 4cm 长的正中剖腹术。每组各有 10 只动物在术后第 4、7、14、21 和 35 天处死。测量切口的抗张强度，并进行组织学检查。
研究组的中线切口抗张强度、术后第 14 天的急性炎症评分以及术后第 7、14、21 和 35 天的新生血管形成均显著更高。
西地那非可作为促进伤口愈合的辅助因子。
