Scholz Christoph, Toth Bettina, Barthell Elisabeth, Mylonas Ioannis, Weissenbacher Tobias, Friese Klaus, Jeschke Udo
Department of Obstetrics and Gynaecology, Ludwig-Maximilians University, Maistrasse 11, Munich, Germany.
Histol Histopathol. 2009 Apr;24(4):467-71. doi: 10.14670/HH-24.467.
Glycodelin (Gd), previously known as placental protein 14 (PP 14), acts as an immuno-suppressive glycoprotein by suppressing the cytolytic capacity of human natural killer (NK) cells and T-cells in vitro. Glycodelin is expressed in normal glandular epithelium of the endometrium as well as in normal and malignant glandular cells in and outside of the reproductive tract. Recently, Gd expression was demonstrated in normal and cancerous human breast tissue. Paraffin-embedded breast cancer tissue blocks (n=121) were examined for Gd expression. No part of the specimens contained carcinoma in situ. Gd expression was present in lobular and ductal breast carcinoma. We observed expression of Gd in breast cancer independent of grading. With regard to nodal status, no significant differences in the expression of Gd between cancer tissue from patients with or without axillary lymph node metastases were present. However, Gd expression was found to be significantly higher in breast cancer tissue when the staining reaction for steroid receptors was also positive. These results implicate that Gd might be an additional marker for the differentiation of breast cancer tissue. To which extent Gd could serve as an additional indicator for breast cancer survival is part of our ongoing research.
糖蛋白14（Gd），以前称为胎盘蛋白14（PP 14），在体外通过抑制人类自然杀伤（NK）细胞和T细胞的细胞溶解能力，发挥免疫抑制糖蛋白的作用。糖蛋白14在子宫内膜的正常腺上皮以及生殖道内外的正常和恶性腺细胞中均有表达。最近，在正常和癌性人类乳腺组织中也证实了Gd的表达。对121例石蜡包埋的乳腺癌组织块进行了Gd表达检测。标本中无原位癌部分。小叶癌和导管癌中均存在Gd表达。我们观察到乳腺癌中Gd的表达与分级无关。关于淋巴结状态，有或无腋窝淋巴结转移患者的癌组织中Gd表达无显著差异。然而，当类固醇受体染色反应也呈阳性时，发现乳腺癌组织中Gd表达显著更高。这些结果表明，Gd可能是乳腺癌组织分化的另一个标志物。Gd在多大程度上可作为乳腺癌生存的额外指标，是我们正在进行的研究的一部分。
