Malik Fraz Arshad, Sanders Andrew J, Jiang Wen G
Department of Surgery, Cardiff University School of Medicine, Cardiff, UK.
Histol Histopathol. 2009 Apr;24(4):519-30. doi: 10.14670/HH-24.519.
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. In recent years apart from its significant involvement in the suppression of secondary tumours it has also been observed that KAI1/CD82 plays a vital role in virus binding and its entry inside the cell. Decreased expression of KAI1/CD82 molecule results in aggravating cancer progression. Altered expression levels of KAI1/CD82 molecule in different types of human cancer have been implicated as having prognostic value and linking to the long term survival of the patients. Increased level of KAI1/CD82 also results in the suppression of secondary tumour growth. Increased expression of this molecule results in reduced cell invasion and cell migration due to endocytosis of epidermal growth factor receptors (EGFR). Thus, KAI-1/CD82 is a pivotal molecule in the regulation of cancer cells' behaviour and has important clinical and therapeutic implications in cancer.
CD82，也被称为KAI-1，在结构上属于四跨膜蛋白家族，而在功能上被归类为转移抑制基因。KAI1/CD82定位于细胞膜，并与其他四跨膜蛋白、整合素和趋化因子相互作用，这些分别负责细胞迁移、黏附和信号传导。近年来，除了其在抑制继发性肿瘤方面的重要作用外，还观察到KAI1/CD82在病毒结合及其进入细胞的过程中起着至关重要的作用。KAI1/CD82分子表达降低会导致癌症进展加剧。KAI1/CD82分子在不同类型的人类癌症中表达水平的改变被认为具有预后价值，并与患者的长期生存相关。KAI1/CD82水平升高也会导致继发性肿瘤生长受到抑制。该分子表达增加会导致细胞侵袭和迁移减少，这是由于表皮生长因子受体（EGFR）的内吞作用。因此，KAI-1/CD82是调节癌细胞行为的关键分子，在癌症中具有重要的临床和治疗意义。
