Titu Stefan, Grapa Cristiana Maria, Mocan Teodora, Balacescu Ovidiu, Irimie Alexandru
"Iuliu Hatieganu" University of Medicine and Pharmacy, Faculty of Medicine, 400126 Cluj-Napoca, Romania.
Department of Surgical Oncology, The Oncology Institute "Prof. Dr. Ion Chiricuta" Cluj-Napoca, 400015 Cluj-Napoca, Romania.
Cancers (Basel). 2021 Nov 12;13(22):5662. doi: 10.3390/cancers13225662.
Tetraspanins are transmembrane proteins expressed in a multitude of cells throughout the organism. They contribute to many processes that surround cell-cell interactions and are associated with the progress of some diseases, including cancer. Their crucial role in cell physiology is often understated. Furthermore, recent studies have shown their great potential in being used as targeting molecules. Data have suggested the potential of tetraspanins as a targeting vector for nanomediated distribution and delivery for colorectal cancer applications. Our aim is to provide a review on the important part that tetraspanins play in the human organism and highlight their potential use for drug delivery systems using nanotechnology.
四跨膜蛋白是在整个生物体的多种细胞中表达的跨膜蛋白。它们参与了许多围绕细胞间相互作用的过程，并与包括癌症在内的一些疾病的进展相关。它们在细胞生理学中的关键作用常常被低估。此外，最近的研究表明它们在用作靶向分子方面具有巨大潜力。数据表明四跨膜蛋白作为纳米介导的分布和递送的靶向载体在结直肠癌应用中的潜力。我们的目的是综述四跨膜蛋白在人体中所起的重要作用，并强调它们在使用纳米技术的药物递送系统中的潜在用途。
