欧洲线粒体 DNA 单倍群在西班牙北部加利西亚地区髋关节骨关节炎发病中的作用。

Role of European mitochondrial DNA haplogroups in the prevalence of hip osteoarthritis in Galicia, Northern Spain.

机构信息

Osteoarticular and Aging Research Laboratory, Biomedical Center Research, INIBIC Rheumatology Division, CH Universitario A Coruña, Coruña, Spain.

出版信息

Ann Rheum Dis. 2010 Jan;69(1):210-3. doi: 10.1136/ard.2008.105254.

DOI:10.1136/ard.2008.105254

PMID:19224903

Abstract

OBJECTIVE

To analyse the mitochondrial DNA (mtDNA) haplogroups of patients with hip osteoarthritis (OA) and those of healthy controls in a Spanish population.

METHODS

mtDNA haplogroups were assigned to 550 cases of hip OA and 505 clinically asymptomatic controls. Sets of controls with healthy knees and hips (n = 179) and patients with knee and/or hip OA (n = 977) were also analysed in a multivariate analysis after adjusting for sex, age and smoking.

RESULTS

Individuals carrying haplogroup J showed a significantly decreased risk of developing hip OA (OR 0.661; 95% CI 0.440 to 0.993; p = 0.045). In addition to haplogroup J, smoking protected against the development of hip OA (OR 0.543; 95% CI 0.311 to 0.946; p = 0.031). However, no relationship was found between rheumatoid arthritis and mtDNA haplogroups.

CONCLUSION

The results of this study support the hypothesis that the mtDNA haplogroups have a role in the complex osteoarthritic process.

摘要

目的

分析西班牙人群髋骨关节炎（OA）患者与健康对照者的线粒体 DNA（mtDNA）单倍群。

方法

将 mtDNA 单倍群分配给 550 例髋骨 OA 患者和 505 例临床无症状对照者。还对具有健康膝关节和髋关节的对照组（n=179）和膝关节和/或髋关节 OA 患者（n=977）进行了多变量分析，调整了性别、年龄和吸烟因素。

结果

携带单倍群 J 的个体发生髋骨 OA 的风险显著降低（OR 0.661；95% CI 0.440 至 0.993；p=0.045）。除单倍群 J 外，吸烟也可预防髋骨 OA 的发生（OR 0.543；95% CI 0.311 至 0.946；p=0.031）。然而，类风湿关节炎与 mtDNA 单倍群之间没有关系。