Osteoarticular and Aging Research Laboratory, Biomedical Center Research, INIBIC Rheumatology Division, CH Universitario A Coruña, Coruña, Spain.
Ann Rheum Dis. 2010 Jan;69(1):210-3. doi: 10.1136/ard.2008.105254.
To analyse the mitochondrial DNA (mtDNA) haplogroups of patients with hip osteoarthritis (OA) and those of healthy controls in a Spanish population.
mtDNA haplogroups were assigned to 550 cases of hip OA and 505 clinically asymptomatic controls. Sets of controls with healthy knees and hips (n = 179) and patients with knee and/or hip OA (n = 977) were also analysed in a multivariate analysis after adjusting for sex, age and smoking.
Individuals carrying haplogroup J showed a significantly decreased risk of developing hip OA (OR 0.661; 95% CI 0.440 to 0.993; p = 0.045). In addition to haplogroup J, smoking protected against the development of hip OA (OR 0.543; 95% CI 0.311 to 0.946; p = 0.031). However, no relationship was found between rheumatoid arthritis and mtDNA haplogroups.
The results of this study support the hypothesis that the mtDNA haplogroups have a role in the complex osteoarthritic process.
分析西班牙人群髋骨关节炎（OA）患者与健康对照者的线粒体 DNA（mtDNA）单倍群。
将 mtDNA 单倍群分配给 550 例髋骨 OA 患者和 505 例临床无症状对照者。还对具有健康膝关节和髋关节的对照组（n=179）和膝关节和/或髋关节 OA 患者（n=977）进行了多变量分析，调整了性别、年龄和吸烟因素。
携带单倍群 J 的个体发生髋骨 OA 的风险显著降低（OR 0.661；95% CI 0.440 至 0.993；p=0.045）。除单倍群 J 外，吸烟也可预防髋骨 OA 的发生（OR 0.543；95% CI 0.311 至 0.946；p=0.031）。然而，类风湿关节炎与 mtDNA 单倍群之间没有关系。
本研究结果支持 mtDNA 单倍群在复杂的骨关节炎发病过程中起作用的假说。
