Diniz Breno Satler, Nunes Paula Villela, Yassuda Mônica Sanches, Forlenza Orestes Vicente
Department and Institute of Psychiatry, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Dement Geriatr Cogn Disord. 2009;27(3):224-31. doi: 10.1159/000203346. Epub 2009 Feb 19.
BACKGROUND/AIMS: The diagnostic stability of mild cognitive impairment (MCI) on short-term follow-up is a key issue in the characterization of this clinical syndrome. We aim to determine the cognitive outcome after 1 year of follow-up in a cohort of older adults.
Baseline clinical and neuropsychological assessments were carried out in older subjects recruited at a tertiary memory clinic. The subjects were reassessed after 1 year of follow-up with the same clinical and neuropsychological protocol.
A total of 115 older adults, including MCI (n = 54) and controls (n = 61), underwent baseline and follow-up evaluation. Ten subjects classified as MCI at baseline (23%) resumed normal cognitive function and 13 controls (21%) progressed to MCI upon follow-up (chi(2) = 0.015, d.f. = 1, p = 0.90). The subjects diagnosed as having MCI on both assessments were older (p = 0.002) and had a worse global cognitive performance according to the Cambridge Cognitive Test (p = 0.014).
The subjects who maintain the MCI status are older and have a worse baseline cognitive performance as well as multiple cognitive deficits.
背景/目的：轻度认知障碍（MCI）在短期随访中的诊断稳定性是该临床综合征特征描述中的一个关键问题。我们旨在确定一组老年人随访1年后的认知结局。
对在三级记忆诊所招募的老年受试者进行基线临床和神经心理学评估。随访1年后，使用相同的临床和神经心理学方案对受试者进行重新评估。
共有115名老年人，包括MCI患者（n = 54）和对照组（n = 61），接受了基线和随访评估。10名在基线时被分类为MCI的受试者（23%）恢复了正常认知功能，13名对照组受试者（21%）在随访时进展为MCI（χ² = 0.015，自由度 = 1，p = 0.90）。在两次评估中均被诊断为MCI的受试者年龄更大（p = 0.002），根据剑桥认知测试，其整体认知表现更差（p = 0.014）。
维持MCI状态的受试者年龄更大，基线认知表现更差，且存在多种认知缺陷。
