他汀类药物在慢性心力衰竭中的作用。
The role of statins in chronic heart failure.
作者信息
Sadek Mouhannad M, Haddad Taleen, Haddad Haissam
机构信息
Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
出版信息
Curr Opin Cardiol. 2009 Mar;24(2):167-71. doi: 10.1097/HCO.0b013e3283229afb.
PURPOSE OF REVIEW
To discuss unresolved issues and recent findings regarding the use of statins in heart failure.
RECENT FINDINGS
Recent data from Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico--Heart Failure and Controlled Rosuvastatin Multinational Trial in Heart Failure suggest that statins did not have any effect on outcome despite significant reduction in low-density lipoprotein and high sensitivity C-reactive protein.
SUMMARY
Most of the evidence for the use of statins in heart failure originates from retrospective trials and post-hoc analyses, and is not supported by prospective randomized clinical trials. There is no evidence to support initiating statin therapy in patients with symptomatic New York Heart Association II-IV heart failure, regardless of the cause.
综述目的
讨论关于他汀类药物在心力衰竭中应用的未解决问题和近期研究结果。
近期研究结果
来自意大利心肌梗死生存研究组——心力衰竭与瑞舒伐他汀在心力衰竭中的多国对照试验的最新数据表明，尽管低密度脂蛋白和高敏C反应蛋白显著降低，但他汀类药物对结局并无任何影响。
总结
他汀类药物在心力衰竭中应用的大多数证据来自回顾性试验和事后分析，并未得到前瞻性随机临床试验的支持。没有证据支持对有症状的纽约心脏协会II-IV级心力衰竭患者启动他汀类药物治疗，无论病因如何。
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