质子离子液体中蛋清溶菌酶淀粉样原纤维的形成与溶解
Formation and dissolution of hen egg white lysozyme amyloid fibrils in protic ionic liquids.
作者信息
Byrne Nolene, Angell C Austen
机构信息
Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA.
出版信息
Chem Commun (Camb). 2009 Mar 7(9):1046-8. doi: 10.1039/b817590j. Epub 2009 Feb 2.
DOI:10.1039/b817590j
PMID:19225631
Abstract
The formation of amyloid fibrils from non-disease-related proteins demonstrates that any protein can adopt this "rogue" form; we show that it is possible to use protic ionic liquids to fibrilize hen egg white lysozyme, and then subsequently to dissolve the fibrils with up to 72% restoration of enzymatic activity.
摘要
由非疾病相关蛋白质形成淀粉样纤维表明任何蛋白质都可以呈现这种“异常”形式；我们证明使用质子离子液体使鸡蛋清溶菌酶形成纤维，随后溶解这些纤维，酶活性恢复率高达72%是可行的。
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