Söylen Bahar, Hinz Kerstin, Prokein Jana, Becker Hartmut, Schmidtke Jörg, Arslan-Kirchner Mine
Institute of Human Genetics, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.
Neuroradiology. 2009 Jun;51(6):397-400. doi: 10.1007/s00234-009-0508-9. Epub 2009 Feb 19.
This study presents a comparison of established methods for measuring dural ectasia with a new quantitative method of assessing this clinical feature.
Seventeen patients with an identified mutation in FBN1 were examined for dural ectasia. The results were compared with 17 age- and sex-matched controls. Our images were also evaluated using the two methods of quantifying dural ectasia, namely those of Ahn et al. and of Oosterhof et al.
With our method, 80% MFS1 patients and 7% controls fulfilled the criterion for dural ectasia. Using the method of Oosterhof et al., dural ectasia was found in 88% patients with MFS1 and in 47% controls. Using the method of Ahn et al. 76% patients with Marfan syndrome and 29% controls showed dural ectasia.
We present a novel quantitative method of evaluating MRT images for dural ectasia, which, in our own patient cohort, performed better than those previously described.
本研究对测量硬脊膜扩张的既定方法与评估这一临床特征的新定量方法进行了比较。
对17名已确定FBN1基因突变的患者进行硬脊膜扩张检查。将结果与17名年龄和性别匹配的对照者进行比较。我们的图像还使用了两种量化硬脊膜扩张的方法进行评估，即安等人的方法和奥斯特霍夫等人的方法。
采用我们的方法，80%的MFS1患者和7%的对照者符合硬脊膜扩张标准。使用奥斯特霍夫等人的方法，在88%的MFS1患者和47%的对照者中发现硬脊膜扩张。使用安等人的方法，76%的马凡综合征患者和29%的对照者显示有硬脊膜扩张。
我们提出了一种评估磁共振成像（MRT）图像中硬脊膜扩张的新定量方法，在我们自己的患者队列中，该方法比先前描述的方法表现更好。
