Zalavras Charalampos G, Christensen Thomas, Rigopoulos Nikolaos, Holtom Paul, Patzakis Michael J
Department of Orthopaedic Surgery, LAC+USC Medical Center, University of Southern California, Keck School of Medicine, 1200 N. State St. GNH-3900, Los Angeles, CA 90033, USA.
Clin Orthop Relat Res. 2009 Jul;467(7):1715-20. doi: 10.1007/s11999-009-0743-8. Epub 2009 Feb 19.
Information on the microbiology of infections after operative ankle fractures, on the details of a treatment protocol used when the ankle joint is preserved, and on the outcome of this protocol will be helpful for the physicians managing patients with this complex problem. We therefore determined the most common pathogen of these infections, the infection recurrence rate, and the amputation rate. We retrospectively reviewed 26 patients of a mean age of 43 years with infections following operative treatment of ankle fractures. Twenty-one of 26 patients (81%) were compromised hosts according to the Cierny-Mader classification. Patients presenting up to 10 weeks postoperatively were treated by débridement and either hardware retention (if implants were judged stable) or hardware removal (if implants were loose). All patients presenting more than 10 weeks postoperatively underwent débridement and hardware removal, with the exception of one patient who underwent below knee amputation. Staphylococcus aureus was identified in 17 patients (65%) and was oxacillin-resistant in six (23%). The infection recurred in five of 18 patients who were followed up for 8 months on average. Three recurrent infections were controlled with repeat débridement. The remaining two patients underwent below-knee amputation, resulting in amputations in 3 of 18 patients. Infection after operative treatment of ankle fractures is a limb-threatening complication, especially in patients with comorbidities, such as diabetes mellitus. Treatment is challenging with high infection recurrence and amputation rates.
Level IV, therapeutic study case series.
关于踝关节骨折术后感染的微生物学信息、保留踝关节时所用治疗方案的细节以及该方案的治疗结果,将有助于医生处理这一复杂问题的患者。因此,我们确定了这些感染的最常见病原体、感染复发率和截肢率。我们回顾性分析了26例平均年龄43岁的踝关节骨折术后感染患者。根据Cierny-Mader分类,26例患者中有21例(81%)为易感宿主。术后10周内就诊的患者接受清创术,根据情况决定是否保留内固定(如果植入物稳定)或取出内固定(如果植入物松动)。所有术后超过10周就诊的患者均接受清创术和内固定取出术,有1例患者接受了膝下截肢术。17例患者(65%)鉴定出金黄色葡萄球菌,其中6例(23%)对苯唑西林耐药。平均随访8个月的18例患者中有5例感染复发。3例复发性感染通过重复清创得到控制。其余2例患者接受了膝下截肢术,18例患者中有3例截肢。踝关节骨折术后感染是一种威胁肢体的并发症,尤其是在患有糖尿病等合并症的患者中。治疗具有挑战性,感染复发率和截肢率都很高。
IV级,治疗性研究病例系列。