18F-氟脱氧葡萄糖正电子发射断层显像/计算机断层扫描（FDG PET/CT）与传统成像在横纹肌肉瘤分期中的对比研究

Comparative study of FDG PET/CT and conventional imaging in the staging of rhabdomyosarcoma.

作者信息

Tateishi Ukihide, Hosono Ako, Makimoto Atsushi, Nakamoto Yuki, Kaneta Tomohiro, Fukuda Hiroshi, Murakami Koji, Terauchi Takashi, Suga Tsuyoshi, Inoue Tomio, Kim Edmund E

机构信息

Department of Radiology, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.

出版信息

Ann Nucl Med. 2009 Feb;23(2):155-61. doi: 10.1007/s12149-008-0219-z. Epub 2009 Feb 19.

DOI:10.1007/s12149-008-0219-z

PMID:19225939

Abstract

OBJECTIVE

The current study was conducted to compare the diagnostic accuracy between (18)F-fluoro-2-deoxy-D: -glucose (FDG) positron emission tomography (PET)/computed tomography (CT), and conventional imaging (CI) for the staging and re-staging of patients with rhabdomyosarcomas.

METHODS

Thirty-five patients who underwent FDG PET/CT prior to treatment were evaluated retrospectively. CI methods consisted of (99m)Tc-hydroxymethylene diphosphonate bone scintigraphy, chest radiograph, whole body CT, and magnetic resonance imaging of the primary site. The images were reviewed and two boardcertified radiologists reached a diagnostic consensus. Tumor stage was confirmed by histological examination and/or follow-up examinations.

RESULTS

Interpretation on the basis of FDG PET/CT, and CI, diagnostic accuracies of the T and N stages were similar. Using FDG PET/CT, the M stage was correctly assigned in 31 patients (89%), whereas the accuracy of CI in M stage was 63%. TNM stage was correctly assessed with FDG PET/CT in 30 of 35 patients (86%) and with CI in 19 of 35 patients (54%). The overall TNM staging and M staging accuracies of FDG PET/CT were significantly higher than that of CI (P < 0.01).

CONCLUSIONS

FDG PET/CT is more accurate than CI regarding clinical staging and re-staging of patients with rhabdomyosarcomas.

摘要

目的

本研究旨在比较¹⁸F-氟-2-脱氧-D-葡萄糖（FDG）正电子发射断层扫描（PET）/计算机断层扫描（CT）与传统成像（CI）在横纹肌肉瘤患者分期及再分期中的诊断准确性。

方法

对35例治疗前行FDG PET/CT检查的患者进行回顾性评估。CI方法包括⁹⁹ᵐTc-亚甲基二膦酸盐骨闪烁显像、胸部X线片、全身CT以及原发部位的磁共振成像。对图像进行分析，两名具有专业资质的放射科医生达成诊断共识。肿瘤分期通过组织学检查和/或随访检查确定。

结果

基于FDG PET/CT和CI的解读，T分期和N分期的诊断准确性相似。使用FDG PET/CT，31例患者（89%）的M分期判断正确，而CI对M分期的准确性为63%。35例患者中，FDG PET/CT正确评估TNM分期的有30例（86%），CI正确评估的有19例（54%）。FDG PET/CT的总体TNM分期和M分期准确性显著高于CI（P<0.01）。