视神经炎进展为多发性硬化症：一项针对意大利人群的前瞻性研究。

Progression of optic neuritis to multiple sclerosis: a prospective study in an Italian population.

作者信息

Mapelli G, Pavoni M, De Palma P, Modestino R, Pavoni V

机构信息

Institute of Neurology, University of Ferrara, Italy.

出版信息

Neuroepidemiology. 1991;10(3):117-21. doi: 10.1159/000110256.

DOI:10.1159/000110256

PMID:1922644

Abstract

We prospectively studied 40 patients with uncomplicated optic neuritis (ON) to determine the risk of subsequent multiple sclerosis (MS). All patients were followed for at least 12 years. Ten patients (25%) developed MS. Seven of these 10 patients developed MS within 2 years. Both sexes were at high risk if ON occurred between the ages of 21 and 40. There was an overall increased risk of MS with recurrent ON. The course of MS appeared to be fairly benign during the period of observation.

摘要

我们对40例单纯性视神经炎（ON）患者进行了前瞻性研究，以确定其后发生多发性硬化症（MS）的风险。所有患者均随访至少12年。10例患者（25%）发生了MS。这10例患者中有7例在2年内发生了MS。如果视神经炎发生在21岁至40岁之间，男女均处于高风险。复发性视神经炎会使MS的总体风险增加。在观察期内，MS的病程似乎相当良性。