Baser S M, Meer J, Polinsky R J, Hallett M
Clinical Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
Neurology. 1991 Oct;41(10):1564-6. doi: 10.1212/wnl.41.10.1564.
We measured sweat production to direct gland stimulation with intradermal methacholine in patients with autonomic failure and in normal subjects. The sympathetic skin response (SSR) to electrical stimulation was assessed in some of the same subjects. Patients with pure autonomic failure (PAF) and multiple system atrophy (MSA) produced significantly less sweat than controls. None of the patients manifested greater than normal sweat production. Impaired sweat gland function does not differentiate MSA and PAF. The SSR did not correlate with sweat response to methacholine. An SSR can occur in the absence of normal sweat gland function. The diminished production of sweat in response to intradermal methacholine in PAF suggests that human sweat glands do not develop chronic denervation supersensitivity. Intradermal methacholine is a simple method to assess sweat gland function.
我们在自主神经功能衰竭患者和正常受试者中，通过皮内注射乙酰甲胆碱直接刺激汗腺来测量汗液分泌。在部分相同受试者中评估了对电刺激的交感皮肤反应（SSR）。单纯自主神经功能衰竭（PAF）和多系统萎缩（MSA）患者的汗液分泌明显少于对照组。没有患者表现出汗液分泌高于正常水平。汗腺功能受损并不能区分MSA和PAF。SSR与对乙酰甲胆碱的汗液反应不相关。在没有正常汗腺功能的情况下也可能出现SSR。PAF患者对皮内注射乙酰甲胆碱的汗液分泌减少表明，人类汗腺不会发生慢性去神经超敏反应。皮内注射乙酰甲胆碱是评估汗腺功能的一种简单方法。
