Gao Fei, Su Zhi-Guo, Wang Ping, Ma Guang-Hui
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
Langmuir. 2009 Apr 9;25(6):3832-8. doi: 10.1021/la804173b.
A novel form of microcapsules, which possess single hollow cavities and thickness-controllable shells, were prepared by a two-step emulsification, emulsion ripening, and suspension polymerization. Parameters on morphology control of water-in-oil-in-water (W/O/W) emulsion globules were particularly investigated in this study, and a universal strategy to prepare single-core water-in-oil (W/O) globules from their multicore precursors was proposed. These single-core globules were further utilized as templates for solid microcapsules by the suspension polymerization, during which the phase-separation mechanism could be employed to form nanochannels across the shells. Such microcapsules could be further exploited as microreactors with functional cores to be loaded and would be especially suitable to encage bioactive materials.
通过两步乳化、乳液熟化和悬浮聚合制备了一种新型微胶囊，其具有单个中空腔和厚度可控的壳。本研究特别研究了水包油包水（W/O/W）乳液球形态控制的参数，并提出了一种从多核前体制备单核油包水（W/O）球的通用策略。这些单核球进一步用作悬浮聚合制备固体微胶囊的模板，在此过程中可利用相分离机制在壳上形成纳米通道。这种微胶囊可进一步用作装载功能核心的微反应器，特别适合包裹生物活性材料。
