Galietti F, Giorgis G E, Oliaro A, Boaro D, Ardizzi A, Barberis S, Massaglia G M
Ospedale S. Luigi Gonzaga, Orbassano Torino, Università di Torino.
Minerva Med. 1991 Jul-Aug;82(7-8):477-81.
Six dialysed patients affected by tuberculosis involving the respiratory apparatus were included in the study. Antimycobacterial treatment consisted of polychemiotherapeutic combinations using terizidone (TZ). The need to resort to this drug may be explained by the need to exclude normally used drugs (R/AMP, INH, SM) due to resistance, allergy or organ meiopragia. Five patients received terizidone at a dose of 600-900 mg/day for the entire course of treatment, whereas it was necessary to abandon treatment in one patient due to the onset of depressive symptoms which then rapidly regressed following the suspension of TZ therapy. The good level of tolerance demonstrated in the 5 remaining cases confirm the inclusion of this drug in the treatment of a limited number of cases of tuberculosis in dialysed patients.
本研究纳入了6例患有累及呼吸器官的结核病的透析患者。抗分枝杆菌治疗采用含特立齐酮（TZ）的多药联合化疗方案。由于耐药、过敏或器官功能障碍而需要排除常用药物（利福平/异烟肼、异烟肼、链霉素），因此有必要使用这种药物。5例患者在整个治疗过程中接受了600 - 900毫克/天剂量的特立齐酮治疗，而1例患者因出现抑郁症状而不得不停止治疗，但在停用TZ治疗后抑郁症状迅速消退。其余5例患者表现出的良好耐受性证实了该药可用于治疗少数透析患者的结核病病例。
