Sohl S, Renner R, Winter U, Bodendorf M, Paasch U, Simon J C, Treudler R
Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig AöR, Philipp-Rosenthal-Strasse 23-25, 04103 Leipzig.
Hautarzt. 2009 Oct;60(10):826-9. doi: 10.1007/s00105-008-1699-4.
Patients treated with TNF-alpha inhibitors frequently have serum autoantibodies, but only a few develop clinically apparent lupus erythematosus. The TNF-alpha inhibitor adalimumab is a fully humanized antibody and seems to induce autoantibodies less frequently than other drugs of this group. We report on a patient with rheumatoid arthritis, who developed anti-histone antibodies and lupus tumidus after eight months on adalimumab therapy.
接受肿瘤坏死因子-α抑制剂治疗的患者经常会出现血清自身抗体，但只有少数人会发展为临床明显的红斑狼疮。肿瘤坏死因子-α抑制剂阿达木单抗是一种完全人源化抗体，似乎比该类其他药物更少诱导自身抗体产生。我们报告了一名类风湿性关节炎患者，在接受阿达木单抗治疗八个月后出现了抗组蛋白抗体和肿胀性狼疮。
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