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利妥昔单抗治疗异基因造血干细胞移植后膜性肾病:一例报告

Rituximab in post allogeneic hematopoietic stem cell transplantation membranous nephropathy: a case report.

作者信息

Vischini Gisella, Cudillo Laura, Ferrannini Michele, Di Daniele Nicola, Cerretti Raffaella, Arcese William

机构信息

Nephrology and Dialysis Unit, Oncohematology and Transplantation Department, Tor Vergata University, Rome, Italy.

出版信息

J Nephrol. 2009 Jan-Feb;22(1):160-3.

Abstract

Membranous nephropathy (MN) post allogeneic hematopoietic stem cell transplantation (HSCT) is a rare complication with few long-term outcome data. We describe the clinical course and outcome of an adult female patient who developed MN after allogeneic HSCT for follicular non-Hodgkin's lymphoma. MN was treated with methylprednisolone as first-line therapy, then she was changed to rituximab for a relapse. After treatment with rituximab, we observed a progressive decrease of proteinuria and normalization of serum albumin. Seven months after treatment, she remains in remission. No adverse reactions to rituximab were observed throughout follow-up.

摘要

异基因造血干细胞移植(HSCT)后发生的膜性肾病(MN)是一种罕见的并发症,长期预后数据较少。我们描述了一名成年女性患者的临床病程和预后,该患者在接受异基因HSCT治疗滤泡性非霍奇金淋巴瘤后发生了MN。MN的一线治疗为甲泼尼龙,复发后改用利妥昔单抗治疗。使用利妥昔单抗治疗后,我们观察到蛋白尿逐渐减少,血清白蛋白恢复正常。治疗七个月后,她仍处于缓解状态。在整个随访过程中未观察到利妥昔单抗的不良反应。

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