Vischini Gisella, Cudillo Laura, Ferrannini Michele, Di Daniele Nicola, Cerretti Raffaella, Arcese William
Nephrology and Dialysis Unit, Oncohematology and Transplantation Department, Tor Vergata University, Rome, Italy.
J Nephrol. 2009 Jan-Feb;22(1):160-3.
Membranous nephropathy (MN) post allogeneic hematopoietic stem cell transplantation (HSCT) is a rare complication with few long-term outcome data. We describe the clinical course and outcome of an adult female patient who developed MN after allogeneic HSCT for follicular non-Hodgkin's lymphoma. MN was treated with methylprednisolone as first-line therapy, then she was changed to rituximab for a relapse. After treatment with rituximab, we observed a progressive decrease of proteinuria and normalization of serum albumin. Seven months after treatment, she remains in remission. No adverse reactions to rituximab were observed throughout follow-up.
异基因造血干细胞移植(HSCT)后发生的膜性肾病(MN)是一种罕见的并发症,长期预后数据较少。我们描述了一名成年女性患者的临床病程和预后,该患者在接受异基因HSCT治疗滤泡性非霍奇金淋巴瘤后发生了MN。MN的一线治疗为甲泼尼龙,复发后改用利妥昔单抗治疗。使用利妥昔单抗治疗后,我们观察到蛋白尿逐渐减少,血清白蛋白恢复正常。治疗七个月后,她仍处于缓解状态。在整个随访过程中未观察到利妥昔单抗的不良反应。