Galan Brandon R, Rovis Tomislav
Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Angew Chem Int Ed Engl. 2009;48(16):2830-4. doi: 10.1002/anie.200804651.
Synthetic sequel: The transition-metal-catalyzed [2+2+2] cycloaddition is an established method for the construction of carbocyclic frameworks but is often plagued by poor selectivity. Recent literature paints a promising picture--a more general metal-catalyzed [2+2+2] cycloaddition can be accomplished intermolecularly using three separate alkynes to furnish highly substituted arenas (see scheme).
过渡金属催化的[2+2+2]环加成反应是构建碳环骨架的一种既定方法,但常常受到选择性差的困扰。近期文献描绘了一幅充满希望的图景——一种更通用的金属催化[2+2+2]环加成反应可以通过分子间使用三种不同的炔烃来实现,以提供高度取代的芳烃(见示意图)。