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[生化标志物在子宫内膜异位症诊断中的应用]

[The use of biochemical markers in diagnosis of endometriosis].

作者信息

Nalbanski A, Kiurkchiev D

出版信息

Akush Ginekol (Sofiia). 2008;47(4):19-22.

PMID:19230253
Abstract

The aim of this study was to evaluate Ca 125 II, C-reactive protein (CRP) and serum amyloid A (SAA) and anticardiolipin antibody (aCL) concentrations for the diagnosis of pelvic endometriosis. The study population consisted of 15 women without endometriosis, as confirmed by laparoscopy (group A), and 35 patients with pelvic endometriosis. All of them were diagnosed by laparoscopy or laparotomy. Group B patients were divided into those at stages I and II of the disease (B I/II) and those at stages III and IV (B III/IV). Blood samples were obtained twice during the menstrual cycle: on day 1-3 of the cycle and on day 8-10 of the cycle. Our results claim that the measurement of these molecules may therefore provide a valuable tool in the diagnosis and management of endometriosis.

摘要

本研究的目的是评估癌抗原125 II(Ca 125 II)、C反应蛋白(CRP)、血清淀粉样蛋白A(SAA)和抗心磷脂抗体(aCL)的浓度,以用于盆腔子宫内膜异位症的诊断。研究对象包括15名经腹腔镜检查确诊无子宫内膜异位症的女性(A组)和35名盆腔子宫内膜异位症患者。所有患者均通过腹腔镜检查或剖腹手术确诊。B组患者分为疾病I期和II期(B I/II)以及III期和IV期(B III/IV)。在月经周期中采集两次血样:在周期的第1 - 3天和第8 - 10天。我们的结果表明,因此这些分子的检测可能为子宫内膜异位症的诊断和管理提供有价值的工具。

相似文献

1
[The use of biochemical markers in diagnosis of endometriosis].[生化标志物在子宫内膜异位症诊断中的应用]
Akush Ginekol (Sofiia). 2008;47(4):19-22.
2
The use of biochemical markers in the diagnosis of pelvic endometriosis.
Hum Reprod. 1997 Nov;12(11):2523-7. doi: 10.1093/humrep/12.11.2523.
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Evaluation of high-sensitivity C-reactive protein in comparison with C-reactive protein as biochemical serum markers in women with endometriosis.评价在子宫内膜异位症女性中,与 C 反应蛋白相比,高敏 C 反应蛋白作为生化血清标志物的价值。
Fertil Steril. 2010 May 1;93(7):2125-9. doi: 10.1016/j.fertnstert.2009.01.072. Epub 2009 Feb 15.
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Use of CA125 fluctuation during the menstrual cycle as a tool in the clinical diagnosis of endometriosis; a preliminary report.利用月经周期中CA125波动作为子宫内膜异位症临床诊断工具的初步报告。
Eur J Obstet Gynecol Reprod Biol. 2004 Sep 10;116(1):85-8. doi: 10.1016/j.ejogrb.2004.02.039.
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Comparison of the clinical value of CA 19-9 versus CA 125 for the diagnosis of endometriosis.CA 19-9与CA 125在子宫内膜异位症诊断中的临床价值比较。
Fertil Steril. 2009 Nov;92(5):1761-3. doi: 10.1016/j.fertnstert.2009.05.022. Epub 2009 Jul 23.
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Non-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers.基于六种血浆生物标志物联合分析的子宫内膜异位症无创诊断。
Hum Reprod. 2010 Mar;25(3):654-64. doi: 10.1093/humrep/dep425. Epub 2009 Dec 9.
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[Correlation between CA-125 marker with the presence and severity of pelvic endometriosis].[CA-125标志物与盆腔子宫内膜异位症的存在及严重程度之间的相关性]
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Use of the concomitant serum dosage of CA 125, CA 19-9 and interleukin-6 to detect the presence of endometriosis. Results from a series of reproductive age women undergoing laparoscopic surgery for benign gynaecological conditions.联合使用血清CA 125、CA 19-9和白细胞介素-6检测子宫内膜异位症的存在。对一系列因良性妇科疾病接受腹腔镜手术的育龄妇女的检测结果。
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The value of serological markers in the diagnosis and prognosis of endometriosis: a prospective case-control study.血清标志物在子宫内膜异位症诊断和预后中的价值:一项前瞻性病例对照研究。
Eur J Obstet Gynecol Reprod Biol. 2011 Feb;154(2):215-7. doi: 10.1016/j.ejogrb.2010.10.008. Epub 2010 Nov 13.
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Serum Ca-125 concentrations in endometriosis.
Acta Eur Fertil. 1989 May-Jun;20(3):137-9.

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