[大型及巨大泌乳素分泌型垂体腺瘤的临床表现、诊断及初始保守治疗结果]

[Clinical presentation, diagnostics and results of primary conservative treatment of large and giant prolactin-secreting pituitary adenomas].

作者信息

Astaf'eva L I, Kadashev B A, Kalinin P L, Kutin M A, Shkarubo A N, Fomichev D V, Faĭzullaev R B, Alekseev S N, Sidneva Iu G, Tenedieva V D, Tropinskaia O F

出版信息

Zh Vopr Neirokhir Im N N Burdenko. 2008 Oct-Dec(4):36-8; discussion 39.

PMID:19230480

Abstract

A prospective study of 55 patients with large and giant prolactin-secreting pituitary tumors receiving dopamine agonists as primary treatment was performed. Statistically significant data were obtained indicating decrease of prolactin level, improvement of vision, normalization of sexual function and shrinking of the tumor. Effectiveness and safety of dopamine agonists in patients with large and giant prolactinomas are proved. Also we discovered possibility of nasal CSF leak during conservative treatment.

摘要

对55例接受多巴胺激动剂作为主要治疗的大泌乳素分泌型垂体瘤和巨大泌乳素分泌型垂体瘤患者进行了一项前瞻性研究。获得了具有统计学意义的数据，表明泌乳素水平降低、视力改善、性功能恢复正常以及肿瘤缩小。证实了多巴胺激动剂对大泌乳素瘤和巨大泌乳素瘤患者的有效性和安全性。我们还发现了保守治疗期间发生鼻脑脊液漏的可能性。