Cornet Muriel, Richard Mathias L, Gaillardin Claude
Microbiologie et Génétique Moléculaire, AgroParisTech, Institut National de la Recherche Agronomique UMR1238, Centre National de la Recherche Scientifique UMR2585, Thiverval-Grignon, France.
Res Microbiol. 2009 Apr;160(3):219-23. doi: 10.1016/j.resmic.2009.02.002. Epub 2009 Feb 20.
In fungi, ambient pH sensing relies on the conserved Rim101 signalling pathway. All components of the pathway have been shown to be functionally conserved in the pathogenic yeast Candida albicans except for Rim9p which, in other fungi, has been suggested to be involved in this process. Here we report that, in C. albicans, the RIM9 homologue is required for Rim-dependent signalling. We also show that overexpressing Vps32p, an endosomal component required for transduction of the pH signal, does not bypass defects in upstream components such as Rim9p, Rim21p and Rim8p.
在真菌中，环境pH感应依赖于保守的Rim101信号通路。除了Rim9p外，该通路的所有组分在致病性酵母白色念珠菌中均已证明具有功能保守性，而在其他真菌中，Rim9p被认为参与了这一过程。在此我们报告，在白色念珠菌中，RIM9同源物是Rim依赖性信号传导所必需的。我们还表明，过表达Vps32p（一种pH信号转导所需的内体组分）并不能绕过上游组分如Rim9p、Rim21p和Rim8p中的缺陷。
