Roberts Gehan, Anderson Peter J, Doyle Lex W
Premature Infant Follow-up Program, The Royal Women's Hospital, Parkville, Australia.
J Pediatr. 2009 Jun;154(6):829-34.e1. doi: 10.1016/j.jpeds.2008.12.036. Epub 2009 Feb 23.
To contrast the rates of neurosensory disabilities at age 8 years in extremely low birth weight (ELBW; birth weight 500 to 999 g) children born in the state of Victoria, Australia in 4 four distinct eras from the late 1970s to the late 1990s.
Study subjects were assessed at age 8 years. Results were compared among 4 ELBW cohorts (87 of 89 children born in 1979-1980, 206 of 212 born in 1985-1987, 224 of 241 born in 1991-1992, and 160 of 170 born in 1997), and between each of these ELBW cohorts and normal birth weight (NBW; birth weight > 2499 g) controls.
The survival rate for ELBW children rose from 25% for the 1979-1980 cohort to 73% for the 1997 cohort. No statistically significant differences in the disability rates were seen in the 4 eras; however, in the 1997 cohort, disability rates were significantly higher in the ELBW children compared with NBW controls: mild disability, 36.7% vs 9.8%; moderate disability, 10.1% vs 2.3%; and severe disability, 8.2% vs 0.6%.
The survival rate of ELBW children continues to rise over time. Despite this, however, the rates of disability in these vulnerable children at school age have remained stable and high relative to controls.
对比20世纪70年代末至90年代末澳大利亚维多利亚州出生的极低出生体重（ELBW；出生体重500至999克）儿童8岁时神经感觉障碍的发生率。
对研究对象在8岁时进行评估。比较了4个极低出生体重队列（1979 - 1980年出生的89名儿童中的87名、1985 - 1987年出生的212名中的206名、1991 - 1992年出生的241名中的224名以及1997年出生的170名中的160名），并将这些极低出生体重队列中的每一个与正常出生体重（NBW；出生体重>2499克）对照组进行比较。
极低出生体重儿童的存活率从1979 - 1980年队列的25%上升到1997年队列的73%。在这4个时期未观察到残疾率有统计学上的显著差异；然而，在1997年队列中，极低出生体重儿童的残疾率显著高于正常出生体重对照组：轻度残疾，36.7%对9.8%；中度残疾，10.1%对2.3%；重度残疾，8.2%对0.6%。
极低出生体重儿童的存活率随时间持续上升。尽管如此，这些脆弱儿童在学龄期的残疾率相对于对照组仍保持稳定且较高。
