Rigoard P, Chaillou M, Fares M, Sottejeau Y, Giot J-P, Honfo-Ga C, Rohan J, Lapierre F, Maixent J-M
Service de neurochirurgie, CHU La Milétrie, 2, rue de La Milétrie, BP 577, 86021 Poitiers cedex, France.
Neurochirurgie. 2009 Mar;55 Suppl 1:S92-103. doi: 10.1016/j.neuchi.2008.06.005. Epub 2009 Feb 23.
Na/K-ATPase electrogenic activity and its indispensable role in maintaining gradients suggest that the modifications in isoform distribution and the functioning of the sodium pump have a major influence on both the neuronal functions, including excitability, and motor efficiency. This article proposes to clarify the involvement of Na/K-ATPase in the transmission of nerve influx within the peripheral nerve and then in the genesis, the maintenance, and the physiology of muscle contraction by comparing the data found in the literature with our work on neuron and muscle characterization of Na/K-ATPase activity and isoforms.
钠钾ATP酶的生电活性及其在维持梯度方面不可或缺的作用表明，亚型分布的改变和钠泵的功能对包括兴奋性在内的神经元功能和运动效率都有重大影响。本文旨在通过将文献中的数据与我们关于钠钾ATP酶活性和亚型的神经元及肌肉特征研究工作进行比较，阐明钠钾ATP酶在周围神经内神经冲动传递中的作用，进而在肌肉收缩的发生、维持及生理学过程中的作用。
