Ali Shadan, Varghese Lalee, Pereira Lucio, Tulunay-Ugur Ozlem E, Kucuk Omer, Carey Thomas E, Wolf Gregory T, Sarkar Fazlul H
Division of Hematology/Oncology, Karmanos Cancer Center, Wayne State University, Detroit, MI, USA.
Department of Pathology, Karmanos Cancer Center, Wayne State University, Detroit, MI, USA.
Cancer Lett. 2009 Jun 18;278(2):201-209. doi: 10.1016/j.canlet.2009.01.009. Epub 2009 Feb 23.
Cisplatin resistance is a major problem in the successful treatment of squamous cell carcinoma (SCC). In the present study we showed, for the first time, that the constitutive activation of NF-kappaB partly contributes to cisplatin resistance and that the inactivation of NF-kappaB by natural agents [G2535 (isoflavone mixture containing genistein and diadzein), 3,3'-diindolylmethane (Bioresponse BR-DIM referred to as B-DIM)] could overcome this resistance, resulting in the inhibition of cell growth and induction of apoptosis, which might be an useful strategy for achieving better treatment outcome in patients diagnosed with cisplatin-resistant tumors of SCC.
顺铂耐药是鳞状细胞癌（SCC）成功治疗中的一个主要问题。在本研究中，我们首次表明，NF-κB的组成性激活部分导致了顺铂耐药，而天然药物[G2535（含染料木黄酮和黄豆苷元的异黄酮混合物）、3,3'-二吲哚甲烷（生物反应BR-DIM，简称B-DIM）]使NF-κB失活可克服这种耐药性，从而抑制细胞生长并诱导凋亡，这可能是在诊断为顺铂耐药SCC肿瘤的患者中取得更好治疗效果的有用策略。
